INFECTIOUS DISEASE

ResponseAdverse effects of antibiotics (including allergy)
Drug interaction eg: warfarin
Increased antimicrobial resistance
C.Diff diarrhoea
Alteration of urinary microbiome resulting in promotion of UTI
Cost

ResponseDecreases renal excretion of drugs that undergo active tubular secretion (weak acids and B-lactam antibiotics)
Pharmacokinetic principal - longer period where drug concentration stays above MIC (Minimum inhibitory concentration)

ResponseInhibitor of bacterial beta lactamases and protect hydrolysable penicillins from inactivation. Weak antibiotic effect in own right. Do not alter the antibacterial spectrum of the parent antibiotics.